The relationship between the transforming growth factor β 1 T29C gene polymorphism and left ventricular geometry and function in hypertensive subjects

Abstract

The distribution of the T29C TGF β 1 gene polymorphism was analyzed in 198 hypertensives with left ventricular hypertrophy (LVH) and in 235 hypertensives without LVH. Circulating TGF β 1 levels, procollagen type III levels, microalbuminuria, and left ventricular geometry and function were evaluated in all the hypertensives with LVH subgrouped according to T29C TGF β 1 gene polymorphism. Circulating TGF β 1 was evaluated by ELISA technique, procollagen type III by a specific radioimmunoassay, microalbuminuria by radioimmunoassay, and left ventricular geometry and function by echocardiography. All groups were comparable for gender, age, and sex. Regarding T29C TGF β 1 gene polymorphism, prevalence of TC or CC genotypes was significantly (P