Fatal nongroupable neisseria meningitidis disease in vaccinated patient receiving eculizumab

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Abstract

Patients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated meningococcal strains. We describe a case in which a nongroupable meningococcal strain, which rarely causes disease in healthy persons, caused fatal disease in an eculizumab recipient despite meningococcal vaccination.

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Nolfi-Donegan, D., Konar, M., Vianzon, V., MacNeil, J., Cooper, J., Lurie, P., … McNamara, L. (2018). Fatal nongroupable neisseria meningitidis disease in vaccinated patient receiving eculizumab. Emerging Infectious Diseases, 24(8), 1561–1564. https://doi.org/10.3201/eid2408.180228

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