Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates and is regulated by blood levels of phosphate and active vitamin D. Post-translational glycosylation by the enzyme GALNT3 and subsequent processing by furin have been demonstrated to be a regulated process that plays a role in regulating FGF23 levels. In physiologic states, FGF23 signaling is mediated by an FGF receptor and the coreceptor, Klotho. Recent work identifying a role for iron/hypoxia pathways in FGF23 physiology and their implications are discussed. Beyond its importance in primary disorders of mineral metabolism, recent work implicates FGF23 in renal disease-associated morbidity, as well as possible roles in cardiovascular disease and skeletal fragility. © 2012.
N., B., W.H., C., R.I., G., & M.T., C. (2012). Fibroblast growth factor 23: State of the field and future directions. Trends in Endocrinology and Metabolism, 23(12), 610–618. Retrieved from http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L52175520