Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway

Citations of this article
Mendeley users who have this article in their library.


We studied the effects of fibroblast growth factor (FGF-10) on alveolar epithelial cell (AEC) Na,K-ATPase regulation. Within 30 min FGF-10 increased Na,K-ATPase activity and α1 protein abundance by 2.5-fold at the AEC plasma membrane. Pretreatment of AEC with the mitogen-activated protein kinase (MAPK) inhibitor U0126, a Grb2-SOS inhibitor (SH3-b-p peptide), or a Ras inhibitor (farnesyl transferase inhibitor (FTI 277)), as well as N17-AEC that express a Ras dominant negative protein each prevented FGF-10-mediated Na,K-ATPase recruitment to the AEC plasma membrane. Accordingly, we provide first evidence that FGF-10 upregulates (short-term) the Na,K-ATPase activity in AEC via the Grb2-SOS/Ras/MAPK pathway. © 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.




Upadhyay, D., Lecuona, E., Comellas, A., Kamp, D. W., & Sznajder, J. I. (2003). Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway. FEBS Letters, 545(2–3), 173–176.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free