Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway

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Abstract

We studied the effects of fibroblast growth factor (FGF-10) on alveolar epithelial cell (AEC) Na,K-ATPase regulation. Within 30 min FGF-10 increased Na,K-ATPase activity and α1 protein abundance by 2.5-fold at the AEC plasma membrane. Pretreatment of AEC with the mitogen-activated protein kinase (MAPK) inhibitor U0126, a Grb2-SOS inhibitor (SH3-b-p peptide), or a Ras inhibitor (farnesyl transferase inhibitor (FTI 277)), as well as N17-AEC that express a Ras dominant negative protein each prevented FGF-10-mediated Na,K-ATPase recruitment to the AEC plasma membrane. Accordingly, we provide first evidence that FGF-10 upregulates (short-term) the Na,K-ATPase activity in AEC via the Grb2-SOS/Ras/MAPK pathway. © 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

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Upadhyay, D., Lecuona, E., Comellas, A., Kamp, D. W., & Sznajder, J. I. (2003). Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway. FEBS Letters, 545(2–3), 173–176. https://doi.org/10.1016/S0014-5793(03)00527-1

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