Fidelity at the Molecular Level: Lessons from Protein Synthesis

0Citations
Citations of this article
437Readers
Mendeley users who have this article in their library.

Abstract

The faithful and rapid translation of genetic information into peptide sequences is an indispensable property of the ribosome. The mechanistic understanding of strategies used by the ribosome to achieve both speed and fidelity during translation results from nearly a half century of biochemical and structural studies. Emerging from these studies is the common theme that the ribosome uses local as well as remote conformational switches to govern induced-fit mechanisms that ensure accuracy in codon recognition during both tRNA selection and translation termination. © 2009 Elsevier Inc. All rights reserved.

Cite

CITATION STYLE

APA

Zaher, H. S., & Green, R. (2009, February 20). Fidelity at the Molecular Level: Lessons from Protein Synthesis. Cell. https://doi.org/10.1016/j.cell.2009.01.036

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free