Fish: A suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities

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Abstract

This review discusses the suitability and advantages of teleost fish for studying underlying mechanisms of normal and pathological development and mineralization of vertebrate skeleton, presents a selection of zebrafish mutants and transgenic lines modeling human skeletal diseases and highlights currently available fish systems for identifying and characterizing novel osteogenic and osteotoxic molecules.

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Laizé, V., Gavaia, P. J., & Cancela, M. L. (2014, February 3). Fish: A suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities. Drug Discovery Today: Disease Models. Elsevier Ltd. https://doi.org/10.1016/j.ddmod.2014.08.001

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