This review discusses the suitability and advantages of teleost fish for studying underlying mechanisms of normal and pathological development and mineralization of vertebrate skeleton, presents a selection of zebrafish mutants and transgenic lines modeling human skeletal diseases and highlights currently available fish systems for identifying and characterizing novel osteogenic and osteotoxic molecules.
Laizé, V., Gavaia, P. J., & Cancela, M. L. (2014, February 3). Fish: A suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities. Drug Discovery Today: Disease Models. Elsevier Ltd. https://doi.org/10.1016/j.ddmod.2014.08.001