Formulation and evaluation of transdermal patches of atenolol

Abstract

This study was carried out to develop matrix based transdermal patches containing Atenolol. A 2 factors HPMC (hydroxyl propyl methyl cellulose) K4M and PVP (Polyvinyl Pyrolidone) 3 level (2 3 ) factorial design was done using Design Expert® which gave 13 experiments. The patches were prepared by Solvent casting method. Propylene glycol (3%) and Tween 80 (6%) were used as plasticizer and permeation enhancer respectively. Physicochemical characteristics and In-Vitro permeation study of formulated transdermal patches were carried out. Contour plot suggested 770mg of PVP and 265mg of HPMC K4M in Optimized formulation.