Formulation and evaluation of transdermal patches of atenolol

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Abstract

Transdermal drug delivery systems are becoming more popular in the field of modern pharmaceutics. The present study was carried out to develop matrix type transdermal patches containing Atenolol with different ratios of HPMC (hydroxyl propyl methyl cellulose) & EC (ethyl cellulose) by solvent casting method. Propylene glycol 3% is used as plasticizer & span 80 is used as permeation enhancer. The possible drugpolymer interactions were studied by FTIR studies. Formulated transdermal patches were evaluated with regard to physicochemical characteristics, in-vitro permeation studies and stability studies. All the prepared formulations showed good physical stability. The in-vitro permeation studies were performed using Franz diffusion cell. Out of all the formulated patches HF4 & HE3 showed good permeation in 24 hrs. So these two formulations were selected as best formulations.

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Budhathoki, U., Gartoulla, M. K., & Shakya, S. (2016). Formulation and evaluation of transdermal patches of atenolol. Indonesian Journal of Pharmacy, 27(4), 196–202. https://doi.org/10.14499/indonesianjpharm27iss4pp196

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