Background . Bullous pemphigoid (BP) is an autoimmune subepidermal blistering skin disorder which occurs mostly in the elderly. Several studies have reported an association between BP and neurological disorders (ND). Objective . The purpose of this study was to evaluate the association between BP and neurological disorders in Iranian patients. Methods . In this cross-sectional study, 87 patients with BP were enrolled. They were compared to 184 controls. Statistical analysis was done by SPSS statistical software version 19. Results . Out of 87 patients with BP, 17 (19.5%) had at least one neurological disease. Cerebrovascular accident (CVA) was the most common neurological disease that was seen in 7 patients (8.0%) in the case group and 4 (2.1%) in the control group. The incidence of CVA was significantly different between BP patients and the control group ( P = 0.022 ). Dementia was observed in 6 patients in the case group (16.8%) and 2 (1.0%) in the control group. The incidence of dementia was significantly different between BP patients and the control group ( P = 0.008 ). In this study, the incidences of Parkinson’s disease ( P = 0.830 ), epilepsy ( P = 0.067 ), and multiple sclerosis ( P = 0.326 ) were not statistically significant between the two groups. Conclusion . The incidence of CVA and dementia in patients with BP compared to the control group was significantly higher.
Khosravani, S., Handjani, F., Alimohammadi, R., & Saki, N. (2017). Frequency of Neurological Disorders in Bullous Pemphigoid Patients: A Cross-Sectional Study. International Scholarly Research Notices, 2017, 1–4. https://doi.org/10.1155/2017/6053267