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Abstract

Objective: To investigate the frequency and risk factors for incident and redetected Chlamydia trachomatis infection in sexually active, young, multi-ethnic women in the community. Design: Cohort study. Setting: 20 London universities and Further Education colleges. Participants: 954 sexually experienced women, mean age 21.5 years (range 16-27), 26% from ethnic minorities, who were recruited to the Prevention of Pelvic Infection (POPI) chlamydia screening trial between 2004 and 2006, and returned repeat postal self-taken vaginal swabs 11-32 (median 16) months after recruitment. Results: The estimated annual incidence of chlamydia infection among 907 women who tested negative at baseline was 3.4 per 100 person-years (95% CI 2.5 to 4.6 per 100 person-years), but 6.6 per 100 person-years (95% CI 4.5 to 9.3 per 100 person-years) in the 326 teenagers (<20 years). Predictors of incident chlamydia infection were age <20 years (relative risk (RR) 4.0, 95% CI 2.1 to 7.5), and (after adjusting for age) a new sexual partner during 12 months follow-up (RR 4.4, 95% CI 2.0 to 9.9), smoking (RR 2.2 95% CI 1.2 to 3.9), concurrent bacterial vaginosis (RR 2.0 95% CI 1.1 to 3.9) and high risk carcinogenic human papillomavirus (RR 2.2, 95% CI 1.1 to 4.3). Of 47 women positive for chlamydia at baseline, 12 (25.5%, 95% CI 13.9% to 40.3%) had redetected infection at a median of 16 months follow-up. Taking into account follow-up time (65 person-years), the annual redetection rate was 18.5 per 100 person-years (95% CI 9.9 to 30.0 per 100 person-years). Conclusions: One in four women with chlamydia infection at baseline retested positive, supporting recent recommendations to routinely retest chlamydia positives.

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A., A., F., R., S., K., P.E., H., H., M., J.S., J., … Oakeshott, P. (2014). Frequency and risk factors for incident and redetected Chlamydia trachomatis infection in sexually active, young, multi-ethnic women: A community based cohort study. Sexually Transmitted Infections, 90(7), 524–528. https://doi.org/10.1136/sextrans-2014-051607 LK  - http://resolver.ebscohost.com/openurl?sid=EMBASE&issn=14723263&id=doi:10.1136%2Fsextrans-2014-051607&atitle=Frequency+and+risk+factors+for+incident+and+redetected+Chlamydia+trachomatis+infection+in+sexually+active%2C+young%2C+multi-ethnic+women%3A+A+community+based+cohort+study&stitle=Sex.+Transm.+Infect.&title=Sexually+Transmitted+Infections&volume=90&issue=7&spage=524&epage=528&aulast=Aghaizu&aufirst=Adamma&auinit=A.&aufull=Aghaizu+A.&coden=STINF&isbn=&pages=

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