Objective: To investigate the frequency and risk factors for incident and redetected Chlamydia trachomatis infection in sexually active, young, multi-ethnic women in the community. Design: Cohort study. Setting: 20 London universities and Further Education colleges. Participants: 954 sexually experienced women, mean age 21.5 years (range 16-27), 26% from ethnic minorities, who were recruited to the Prevention of Pelvic Infection (POPI) chlamydia screening trial between 2004 and 2006, and returned repeat postal self-taken vaginal swabs 11-32 (median 16) months after recruitment. Results: The estimated annual incidence of chlamydia infection among 907 women who tested negative at baseline was 3.4 per 100 person-years (95% CI 2.5 to 4.6 per 100 person-years), but 6.6 per 100 person-years (95% CI 4.5 to 9.3 per 100 person-years) in the 326 teenagers (<20 years). Predictors of incident chlamydia infection were age <20 years (relative risk (RR) 4.0, 95% CI 2.1 to 7.5), and (after adjusting for age) a new sexual partner during 12 months follow-up (RR 4.4, 95% CI 2.0 to 9.9), smoking (RR 2.2 95% CI 1.2 to 3.9), concurrent bacterial vaginosis (RR 2.0 95% CI 1.1 to 3.9) and high risk carcinogenic human papillomavirus (RR 2.2, 95% CI 1.1 to 4.3). Of 47 women positive for chlamydia at baseline, 12 (25.5%, 95% CI 13.9% to 40.3%) had redetected infection at a median of 16 months follow-up. Taking into account follow-up time (65 person-years), the annual redetection rate was 18.5 per 100 person-years (95% CI 9.9 to 30.0 per 100 person-years). Conclusions: One in four women with chlamydia infection at baseline retested positive, supporting recent recommendations to routinely retest chlamydia positives.
A., A., F., R., S., K., P.E., H., H., M., J.S., J., … Oakeshott, P. (2014). Frequency and risk factors for incident and redetected Chlamydia trachomatis infection in sexually active, young, multi-ethnic women: A community based cohort study. Sexually Transmitted Infections, 90(7), 524–528. https://doi.org/10.1136/sextrans-2014-051607 LK - http://resolver.ebscohost.com/openurl?sid=EMBASE&issn=14723263&id=doi:10.1136%2Fsextrans-2014-051607&atitle=Frequency+and+risk+factors+for+incident+and+redetected+Chlamydia+trachomatis+infection+in+sexually+active%2C+young%2C+multi-ethnic+women%3A+A+community+based+cohort+study&stitle=Sex.+Transm.+Infect.&title=Sexually+Transmitted+Infections&volume=90&issue=7&spage=524&epage=528&aulast=Aghaizu&aufirst=Adamma&auinit=A.&aufull=Aghaizu+A.&coden=STINF&isbn=&pages=