Full factorial design for optimization, development and validation of HPLC method to determine valsartan in nanoparticles

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Abstract

High performance liquid chromatographic method was optimized, developed and validated as per the ICH guidelines. In this study the 20. mM ammonium formate and acetonitrile in the 57:43 ratio were used as mobile phase for the analysis of valsartan. Full factorial design was used to optimize the effect of variable factors. The responses were peak area, tailing factor and number of theoretical plates. The quadratic effect of flow rate and wavelength individually as well as in interaction were most significant (p

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Kumar, L., Sreenivasa Reddy, M., Managuli, R. S., & Pai K., G. (2015). Full factorial design for optimization, development and validation of HPLC method to determine valsartan in nanoparticles. Saudi Pharmaceutical Journal, 23(5), 549–555. https://doi.org/10.1016/j.jsps.2015.02.001

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