© 2015 Federau et al. Functional imaging with intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) is demonstrated. Images were acquired at 3 Tesla using a standard Stejskal-Tanner diffusion-weighted echo-planar imaging sequence with multiple b-values. Cerebro-spinal fluid signal, which is highly incoherent, was suppressed with an inversion recovery preparation pulse. IVIM microvascular perfusion parameters were calculated according to a twocompartment (vascular and non-vascular) diffusion model. The results obtained in 8 healthy human volunteers during visual stimulation are presented. The IVIM blood flow related parameter fD∗increased 170% during stimulation in the visual cortex, and 70% in the underlying white matter.
Federau, C., O’Brien, K., Birbaumer, A., Meuli, R., Hagmann, P., & Maeder, P. (2015). Functional mapping of the human visual cortex with intravoxel incoherent motion MRI. PLoS ONE, 10(2). https://doi.org/10.1371/journal.pone.0117706