Functions of fibroblast growth factors and their receptors

Abstract

Fibroblast growth factors were first characterized twenty years ago as mitogens of cultured fibroblasts. Despite a wealth of data from experiments in vitro, insights have begun to emerge only recently on the normal function of these growth factors in mice and humans, as a result of studies of natural and experimental mutations in the factors and their receptors. © 1995 Elsevier Science Ltd. All rights reserved.