Functions of PARylation in DNA Damage Repair Pathways

47Citations
Citations of this article
173Readers
Mendeley users who have this article in their library.

Abstract

Protein poly ADP-ribosylation (PARylation) is a widespread post-translational modification at DNA lesions, which is catalyzed by poly(ADP-ribose) polymerases (PARPs). This modification regulates a number of biological processes including chromatin reorganization, DNA damage response (DDR), transcriptional regulation, apoptosis, and mitosis. PARP1, functioning as a DNA damage sensor, can be activated by DNA lesions, forming PAR chains that serve as a docking platform for DNA repair factors with high biochemical complexity. Here, we highlight molecular insights into PARylation recognition, the expanding role of PARylation in DDR pathways, and the functional interaction between PARylation and ubiquitination, which will offer us a better understanding of the biological roles of this unique post-translational modification.

Cite

CITATION STYLE

APA

Wei, H., & Yu, X. (2016, June 1). Functions of PARylation in DNA Damage Repair Pathways. Genomics, Proteomics and Bioinformatics. Beijing Genomics Institute. https://doi.org/10.1016/j.gpb.2016.05.001

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free