Gαq and Gα11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme

46Citations
Citations of this article
37Readers
Mendeley users who have this article in their library.

Abstract

Endothelin-A (ETA) is a G-protein-coupled receptor expressed in the neural crest-derived mesenchyme of the pharyngeal arches during craniofacial development. Targeted deletion of the ETA receptor or its ligand endothelin-1 (ET-1) causes cleft palate and hypoplasia of the mandible, otic cup, and tympanic ring. Previously we showed that Gαq/Gα11-null mice die around E11.0, whereas Gαq(-/-)Gα11(+/-) mice survive to birth with hypomorphic phenotypes similar to, but less severe than, ETA or ET-1-null mice. To determine whether ET-1 signaling is transduced by Gαq/Gα11 proteins, we examined the expression patterns of several ET-1 dependent and independent transcription factors in Gαq/Gα11-deficient embryos. Expression of genes encoding the ET-1-dependent transcription factors Dl×3, Dl×6, dHAND, and eHAND was specifically downregulated in the pharyngeal arches of Gαq/Gα11-deficient mice. In contrast, pharyngeal arch expression of the homeobox gene Msx1, which is not regulated by ET-1 signaling, was maintained in these embryos. We conclude that the Gαq and Gα11 proteins serve as the intracellular mediators of ET-1 signaling in the pharyngeal arch mesenchyme. © 2003 Elsevier Science (USA). All rights reserved.

Cite

CITATION STYLE

APA

Ivey, K., Tyson, B., Ukidwe, P., McFadden, D. G., Levi, G., Olson, E. N., … Wilkie, T. M. (2003). Gαq and Gα11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme. Developmental Biology, 255(2), 230–237. https://doi.org/10.1016/S0012-1606(02)00097-0

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free