G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson’s Disease?

0Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disorder and has plagued humans for more than 200 years. The etiology and detailed pathogenesis of PD is unclear, but is currently believed to be the result of the interaction between genetic and environmental factors. Studies have found that PD patients with the LRRK2:G2019S variation have the typical clinical manifestations of PD, which may be familial or sporadic, and have age-dependent pathogenic characteristics. Therefore, the LRRK2:G2019S variation may be an ideal model to study the interaction of multiple factors such as genetic, environmental and natural aging factors in PD in the future. This article reviewed the progress of LRRK2:G2019S studies in PD research in order to provide new research ideas and directions for the pathogenesis and treatment of PD.

Cite

CITATION STYLE

APA

Ren, C., Ding, Y., Wei, S., Guan, L., Zhang, C., Ji, Y., … Yin, P. (2019, September 4). G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson’s Disease? Frontiers in Human Neuroscience. Frontiers Media S.A. https://doi.org/10.3389/fnhum.2019.00306

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free