Gaucher Disease: Forging a New Path to the Lysosome

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Abstract

Most lysosomal proteins are tagged with a carbohydrate modification that allows their recognition and transport to the lysosome. In this issue, Reczek et al. (2007) identify a new pathway for protein sorting to the lysosome. They show that β-glucocerebrosidase-the lysosomal enzyme defective in patients with Gaucher disease-is delivered to the lysosome through its interaction with the transmembrane protein LIMP-2. © 2007 Elsevier Inc. All rights reserved.

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Griffiths, G. M. (2007, November 16). Gaucher Disease: Forging a New Path to the Lysosome. Cell. https://doi.org/10.1016/j.cell.2007.10.043

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