Gene expression profiling for in silico microdissection of Hodgkin's lymphoma microenvironment and identification of prognostic features

2Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

Gene expression profiling studies based on DNA microarrays have demonstrated their ability to define the interaction pathways between neoplastic and nonmalignant stromal cells in cancer tissues. During the past ten years, a number of approaches including microdissection have tried to resolve the variability in DNA microarray measurements stemming from cancer tissue sample heterogeneity. Another approach, designated as virtual or in silico microdissection, avoids the laborious and time-consuming step of anatomic microdissection. It consists of confronting the gene expression profiles of complex tissue samples to those of cell lines representative of different cell lineages, different differentiation stages, or different signaling pathways. This strategy has been used in recent studies aiming to analyze microenvironment alterations using gene expression profiling of nonmicrodissected classical Hodgkin lymphoma tissues in order to generate new prognostic factors. These recent contributions are detailed and discussed in the present paper. Copyright © 2011 François Bertucci et al.

Cite

CITATION STYLE

APA

Xerri, L., Bertucci, F., & Chetaille, B. (2011). Gene expression profiling for in silico microdissection of Hodgkin’s lymphoma microenvironment and identification of prognostic features. Advances in Hematology. https://doi.org/10.1155/2011/485310

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free