Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis

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Abstract

Inositol 1,4,5-trisphosphate receptors (IP3R1, 2, and 3) are intracellular Ca2+ release channels that regulate various vital processes. Although the ryanodine receptor type 2, another type of intracellular Ca2+ release channel, has been shown to play a role in embryonic cardiomyocytes, the functions of the IP3Rs in cardiogenesis remain unclear.

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Uchida, K., Aramaki, M., Nakazawa, M., Yamagishi, C., Makino, S., Fukuda, K., … Yamagishi, H. (2010). Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis. PLoS ONE, 5(9), 1–10. https://doi.org/10.1371/journal.pone.0012500

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