Gene length matters in neurons

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Abstract

A recent study by Gabel etal. (2015) found that Mecp2, the gene mutated in Rett syndrome, represses long (>100 kb) genes associated with neuronal physiology and connectivity by binding to methylated CA sites in DNA. This study adds to a growing body of literature implicating gene length and transcriptional mechanisms in neurodevelopmental and neurodegenerative disorders. A recent study by Gabel etal. (2015) found that Mecp2, the gene mutated in Rett syndrome, represses long (> 100 kb) genes associated with neuronal physiology and connectivity by binding to methylated CA sites in DNA. This study adds to a growing body of literature implicating gene length and transcriptional mechanisms in neurodevelopmental and neurodegenerative disorders.

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Zylka, M. J., Simon, J. M., & Philpot, B. D. (2015, April 22). Gene length matters in neurons. Neuron. Cell Press. https://doi.org/10.1016/j.neuron.2015.03.059

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