Gene modification strategies to induce tumor immunity

Citations of this article
Mendeley users who have this article in their library.


The immune system provides an attractive option for use in cancer therapy. Our increasing understanding of the molecular events important in the generation of an effective immune response presents us with the opportunity to manipulate key genes to boost the immune response against cancer. Genetic modification is being employed to enhance a range of immune processes including antigen presentation, activation of specific T cells, and localization of immune effectors to tumors. In this review, we describe how many diverse cell types, including dendritic cells, T cells, and tumor cells, are being modified with a variety of genes, including those encoding antigens, cytokines, and chemokines, in order to enhance tumor immunity. Copyright ©2005 by Elsevier Inc.




Murphy, A., Westwood, J. A., Teng, M. W. L., Moeller, M., Darcy, P. K., & Kershaw, M. H. (2005). Gene modification strategies to induce tumor immunity. Immunity. Cell Press.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free