The sequences of some gene regulatory elements diverge considerably, even between closely related species. A detailed analysis of the fast-evolving sparkling enhancer in Drosophila now identifies key compensatory mechanisms and 'grammar' elements that are critical for maintaining functional integrity. © 2011 Elsevier Ltd All rights reserved.
Datta, R. R., & Small, S. (2011, July 26). Gene regulation: Piecing together the puzzle of enhancer evolution. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2011.06.026