The Generation R Study: A Review of Design, Findings to Date, and a Study of the 5-HTTLPR by Environmental Interaction From Fetal Life Onward

  • Tiemeier MD, PhD H
  • Velders MD F
  • Szekely MSc E
  • et al.
ISSN: 08908567
N/ACitations
Citations of this article
1Readers
Mendeley users who have this article in their library.

Abstract

First, we give an overview of child psychiatric research in the Generation R Study, a population-based cohort from fetal life forward. Second, we examine within Generation R whether the functional polymorphism (5-HTTLPR) in the promoter of the serotonin transporter gene interacts with prenatal maternal chronic difficulties, prenatal maternal anxiety or postnatal maternal anxiety to influence child emotional development. A total of 2,136 northern European children were genotyped for 5-HTTLPR and rs25531. Mothers reported chronic difficulties and anxiety symptoms at 20 weeks' pregnancy and when the child was 3 years old. Child emotion recognition was observed at 3 years, and child emotional problems were assessed with the CBCL/1...-5 at 5 years. There were consistent main effects of maternal difficulties and anxiety on child emotional problems, but no main effect of 5-HTTLPR. Moreover, children with the s allele were at increased risk for emotional problems if their mothers reported prenatal anxiety symptoms (... = 2.02, p < .001) or postnatal anxiety symptoms (... = 1.64, p < 0.001). Also, in children of mothers with prenatal anxiety symptoms, the s allele was associated with less accurate emotion-matching (... = -0.11, p = .004). This population-based study shows that vulnerability due to 5-HTTLPR is not specific for certain adverse exposures or severe events, but suggests that the small effects of gene-environment interaction on emotional development become manifest early in life. (ProQuest: ... denotes formulae/symbols omitted.)

Cite

CITATION STYLE

APA

Tiemeier  MD, PhD, H., Velders  MD, F. P., Szekely  MSc, E., Roza  MD, PhD, S. J., Dieleman  MD, G., Jaddoe  MD, PhD, V. W. V., … Verhulst  MD, PhD, F. C. (2012). The Generation R Study: A Review of Design, Findings to Date, and a Study of the 5-HTTLPR by Environmental Interaction From Fetal Life Onward. Journal of the American Academy of Child and Adolescent Psychiatry, 51(11), 1119. Retrieved from https://search.proquest.com/docview/1115383244?accountid=17215 http://limo.libis.be/resolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Acentral&atitle=The+Generation+R+Study%3A+A+Review+of+Design%2C+Findings

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free