Genetic susceptibility to total hip arthroplasty failure: A case-control study on the influence of MMP 1 gene polymorphism

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Abstract

Background: Genetic factors plays an important role in early failure of total hip arthroplasty (THA) etiology and MMP-1 gene polymorphism rs5854 may be involved. The present study was conducted to reveal the possible association between MMP-1 rs5854 C/T polymorphism and the risk of early failure of THA (aseptic loosening).Methods: The rs5854 single nucleotide polymorphism (SNP) in MMP-1 gene was genotyped in 63 subjects who were diagnosed as aseptic loosening after total hip arthroplasty within 10 years and in 81 age and gender matched controls.Results: The genotype frequencies of the MMP-1 rs5854 C/T polymorphism were 57.1% (CC), 28.6% (CT), and 14.3% (TT) in patients with failure of THA, and 79.0% (CC), 17.3% (CT), and 3.7% (TT) in the controls (P = 0.0099). Rs5854 polymorphism was found to be significantly associated with increased risk of aseptic loosening.Conclusion: The results showed the rs5854 SNP was associated with increased risk of the early aseptic loosening susceptibility.Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_177.

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Yan, Y., Hu, J., Lu, H., & Wang, W. (2014). Genetic susceptibility to total hip arthroplasty failure: A case-control study on the influence of MMP 1 gene polymorphism. Diagnostic Pathology, 9(1). https://doi.org/10.1186/s13000-014-0177-9

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