Staphylococcus aureus ST291 has been reported as a homologue recombinant double locus variant of the livestock associated S. aureus ST398. However, whole genome sequencing show that ST291 is a unique genetic lineage with highly variable content within its accessory genome compared to both human and livestock associated genome sequenced CC398s. © 2013 Stegger et al.
Stegger, M., Aziz, M., Chroboczek, T., Price, L. B., Ronco, T., Kiil, K., … Andersen, P. S. (2013). Genome Analysis of Staphylococcus aureus ST291, a Double Locus Variant of ST398, Reveals a Distinct Genetic Lineage. PLoS ONE, 8(5). https://doi.org/10.1371/journal.pone.0063008