Genome assembly forensics: Finding the elusive mis-assembly

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Abstract

We present the first collection of tools aimed at automated genome assembly validation. This work formalizes several mechanisms for detecting mis-assemblies, and describes their implementation in our automated validation pipeline, called amosvalidate. We demonstrate the application of our pipeline in both bacterial and eukaryotic genome assemblies, and highlight several assembly errors in both draft and finished genomes. The software described is compatible with common assembly formats and is released, open-source, at http://amos.sourceforge.net. © 2008 Phillippy et al.; licensee BioMed Central Ltd.

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Phillippy, A. M., Schatz, M. C., & Pop, M. (2008). Genome assembly forensics: Finding the elusive mis-assembly. Genome Biology, 9(3). https://doi.org/10.1186/gb-2008-9-3-r55

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