Recent studies in yeast have shed light on the molecular mechanisms by which telomere dysfunction leads to chromosome fusions. Furthermore, examination of the consequences of telomerase loss in mice suggests that only a few critically short telomeres may be sufficient to promote genomic instability.
Lundblad, V. (2001, November 27). Genome instability: McClintock revisited. Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(01)00573-5