We used paired-end Illumina deep sequencing and de novo assembly to determine the genome sequence of herpes simplex virus 1 (HSV-1) strain MacIntyre (aka McIntyre). The MacIntyre strain originated from the brain of a patient with lethal HSV encephalitis and has a unique limitation in its neuronal spread, moving solely in the retrograde direction.
Szpara, M. L., Tafuri, Y. R., Parsons, L., Shreve, J. T., Engel, E. A., & Enquist, L. W. (2014). Genome Sequence of the Anterograde-Spread-Defective Herpes Simplex Virus 1 Strain MacIntyre. Genome Announcements, 2(6). https://doi.org/10.1128/genomea.01161-14