The octanoylated peptide hormone ghrelin regulates episodic growth hormone release and energy balance. Work in genetically modified mice (Kirchner et al., 2009) now shows that in vivo activity of ghrelin O-acyltransferase (GOAT), responsible for ghrelin octanoylation, decreases during fasting but increases after ingesting medium-chain fatty acid triglycerides (MCT). © 2009 Elsevier Inc. All rights reserved.
Smith, R. G. (2009, August 6). From GH to Billy Ghrelin. Cell Metabolism. https://doi.org/10.1016/j.cmet.2009.07.009