Grape seed proanthocyanidin extract and swimming training enhances neuronal number in dorso-medial prefrontal cortex in middle-aged male rats by alleviating oxidative stress

0Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.

Abstract

The dorsomedial prefrontal cortex (dmPFC) is critical for working memory, which declines with age. The mechanisms for aging dmPFC are oxidative stress, antioxidant defense and anatomical alterations. This study was carried out to test whether swimming training and grape seed proanthocyanidin extract (GSPE) are suitable interventions for curtailing free radical generation in the dmPFC in middle-aged male rats. The results indicated that superoxide and hydrogen peroxide increased in the middle-aged, as did lipid and protein oxidations, while superoxide dismutase and catalase activity decreased. There were positive correlations between age and lipofuscin. Importantly, the rats experienced reductions in neuronal number, volume and density in the dmPFC. Rats under combined interventions displayed more alleviation of the age changes than rats with single interventions suggesting the possibilities of utilizing GSPE as a functional supplement in conjunction with swimming exercise towards improving neuronal survivability, and preventing cognitive decline beyond middle-age.

Cite

CITATION STYLE

APA

Abhijit, S., Tripathi, S. J., Shankaranarayana Rao, B. S., & Asha Devi, S. (2020). Grape seed proanthocyanidin extract and swimming training enhances neuronal number in dorso-medial prefrontal cortex in middle-aged male rats by alleviating oxidative stress. Journal of Functional Foods, 64. https://doi.org/10.1016/j.jff.2019.103693

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free