Haemolytic-uraemic syndrome with bacteraemia caused by a new hybrid Escherichia coli pathotype

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Abstract

We describe a new atypical Shiga-toxin-producing Escherichia coli (STEC) responsible for a severe episode of haemolytic-uraemic syndrome in an adult with a relapse associated with bacteraemia. This STECs train of serotype O80:H2 harboured stx2c and stx2d gene subtypes, the rare eae ? variant and a ColV plasmid with a conserved virulence plasmidic region involved in virulence of human and avian extraintestinal pathogenic E. coli. This atypical hybrid pathotype, which represents a new threat, is a further demonstration that STEC may be a recipient for extraintestinal virulence factors and raises again the question of antibiotic therapy during STEC infection.

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Mariani-Kurkdjian, P., Lemâitre, C., Bidet, P., Perez, D., Boggini, L., Kwon, T., & Bonacorsi, S. (2014). Haemolytic-uraemic syndrome with bacteraemia caused by a new hybrid Escherichia coli pathotype. New Microbes and New Infections, 2(4), 127–131. https://doi.org/10.1002/nmi2.49

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