Halting metastasis through CXCR4 inhibition

39Citations
Citations of this article
51Readers
Mendeley users who have this article in their library.

Abstract

Metastasis occurs when cancer cells leave the primary tumor site and migrate to distant parts of the body. The CXCR4-SDF-1 pathway facilitates this migration, and its expression has become the hallmark of several metastatic cancers. Targeted approaches are currently being developed to inhibit this pathway, and several candidates are now in clinical trials. Continued exploration of CXCR4 inhibitors will generate compounds that have improved activity over current candidates.

Cite

CITATION STYLE

APA

Ramsey, D. M., & McAlpine, S. R. (2013, January 1). Halting metastasis through CXCR4 inhibition. Bioorganic and Medicinal Chemistry Letters. Elsevier Ltd. https://doi.org/10.1016/j.bmcl.2012.10.138

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free