Harnessing the placebo effect in pediatric migraine clinic

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This article focuses on how physicians may take advantage of high pediatric placebo responsivity in the migraine clinic to optimize treatment outcomes and to provide patients with an additional therapeutic placebo benefit. The authors review current pediatric migraine treatments, summarize candidate mechanisms underlying clinical relevant placebo effects, and conclude by suggesting ways to maximize the clinical value of this psychobiological response in pediatric migraine practice. Because pharmacologic and non-pharmacologic therapies are administered into a complex living being and in a particular context, it is not surprising that expectations and beliefs play a substantial role in shaping the outcome of these therapies, especially in pediatric populations. High placebo response rates, as noted in pediatric migraine trials, can adversely impact the evaluation of new treatments but they may also provide welcome therapeutic benefit in clinical practice. In pediatric migraine, it is well documented but often overlooked that both environmental factors and endogenous physiological mechanisms play a central role in controlling pediatric migraine attacks.Hence, disregarding physicians’ power in inducing analgesic states during the therapeutic encounter can be considered sub-optimal care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)




Faria, V., Linnman, C., Lebel, A., & Borsook, D. (2014, October 1). Harnessing the placebo effect in pediatric migraine clinic. Journal of Pediatrics. Mosby Inc. https://doi.org/10.1016/j.jpeds.2014.06.040

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