Harrisotones A-E, five novel prenylated polyketides with a rare spirocyclic skeleton from Harrisonia perforata

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Abstract

Five novel prenylated polyketides, harrisotones A-E (1-5) representing a rare spirocyclic skeleton, along with a new hydroperoxypolyketide harrisonol A (6), were isolated from the stems and leaves of Harrisonia perforata. The structures of harrisotones A-E (1-5) were extensively elucidated on the basis of spectroscopic analysis, especially 2D NMR and CD spectra. A plausible origin of compounds 1-5 was rationalized biogenetically, and traced back to harrisonol A (6). Harrisotones A-C (1-3) and harrisonol A (6) exhibited significant cytotoxicity against P-388 and/or A-549 tumor cell lines. © 2008 Elsevier Ltd. All rights reserved.

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Yin, S., Chen, X., Su, Z. S., Yang, S. P., Fan, C. Q., Ding, J., & Yue, J. M. (2009). Harrisotones A-E, five novel prenylated polyketides with a rare spirocyclic skeleton from Harrisonia perforata. Tetrahedron, 65(6), 1147–1152. https://doi.org/10.1016/j.tet.2008.11.068

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