Heart Rate Variability Is Associated with Survival in Patients with Brain Metastasis: A Preliminary Report

  • Wang Y
  • Wu H
  • Huang E
  • et al.
N/ACitations
Citations of this article
32Readers
Mendeley users who have this article in their library.

Abstract

Impaired heart rate variability (HRV) has been demonstrated as a negative survival prognosticator in various diseases. We conducted this prospective study to evaluate how HRV affects brain metastasis (BM) patients. Fifty-one BM patients who had not undergone previous brain operation or radiotherapy (RT) were recruited from January 2010 to July 2012, and 40 patients were included in the final analysis. A 5-minute electrocardiogram was obtained before whole brain radiotherapy. Time domain indices of HRV were compared with other clinical factors on overall survival (OS). In the univariate analysis, Karnofsky performance status (KPS) <70 ( P=0.002 ) and standard deviation of the normal-to-normal interval (SDNN) <10 ms ( P=0.004 ) significantly predict poor survival. The multivariate analysis revealed that KPS <70 and SDNN <10 ms were independent negative prognosticators for survival in BM patients with hazard ratios of 2.657 and 2.204, respectively. In conclusion, HRV is associated with survival and may be a novel prognostic factor for BM patients.

Cite

CITATION STYLE

APA

Wang, Y.-M., Wu, H.-T., Huang, E.-Y., Kou, Y. R., & Hseu, S.-S. (2013). Heart Rate Variability Is Associated with Survival in Patients with Brain Metastasis: A Preliminary Report. BioMed Research International, 2013, 1–6. https://doi.org/10.1155/2013/503421

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free