Helicobacter pylori resistance to antibiotics in 2014 in France detected by phenotypic and genotypic methods

28Citations
Citations of this article
25Readers
Mendeley users who have this article in their library.

Abstract

A large survey of antimicrobial resistance of Helicobacter pylori was performed in France in 2014: 984 patients were enrolled by 75 gastroenterologists all over the country. Among the 783 patients who had never received eradication treatment before, 266 (33.9%) were H. pylori positive. The strains showed a high rate of clarithromycin resistance (22.2%), moderate rate of resistance to levofloxacin (15.4%) and high rate of resistance to metronidazole (45.9%). In all, 187 patients had received previous treatment, of which 115 were H. pylori positive with very high resistance to clarithromycin (73.9%) and metronidazole (78.3%). None of the patients receiving PYLERA (Bismuth salt-Tetracycline HCl-Metronidazole) proton-pump inhibitor developed resistance to tetracycline. A real-time PCR applied to gastric biopsy specimens detected all the cases that were positive by culture as well as 30 additional cases. A good correlation was found between the clarithromycin resistance detected by phenotypic methods and the associated mutations for clarithromycin resistance, which has continued to increase in the last decade but at a lower rate than previously observed.

Cite

CITATION STYLE

APA

Ducournau, A., Bénéjat, L., Sifré, E., Bessède, E., Lehours, P., & Mégraud, F. (2016). Helicobacter pylori resistance to antibiotics in 2014 in France detected by phenotypic and genotypic methods. Clinical Microbiology and Infection, 22(8), 715–718. https://doi.org/10.1016/j.cmi.2016.06.003

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free