Alveolar echinococcosis (AE) is a severe chronic hepatic parasitic disease currently emerging in central and eastern Europe. Untreated AE presents a high mortality (>90%) due to a severe hepatic destruction as a result of parasitic metacestode proliferation which behaves like a malignant tumor. Despite this severe course and outcome of disease, the genetic program that regulates the host response leading to organ damage as a consequence of hepatic alveolar echinococcosis is largely unknown.
Gottstein, B., Wittwer, M., Schild, M., Merli, M., Leib, S. L., Müller, N., … Jaggi, R. (2010). Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs. PLoS ONE, 5(4). https://doi.org/10.1371/journal.pone.0009779