Hepatitis B genotypes correlate with tumor recurrence after curative resection of hepatocellular carcinoma

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Background & Aims: Hepatitis B virus (HBV) genotype C is associated with the development of hepatocellular carcinoma (HCC), compared with genotype B. This study aims to investigate whether HBV genotypes influence the clinicopathologic features and long-term prognosis of patients after curative resection of HCC. Methods: Stored serum samples from 62 patients with HBV-related HCC were tested for HBV genotype using a molecular method. Results: Sixty of 62 patients (96.8%) undergoing curative resection of HCC were infected with genotype B or C. Concomitant cirrhosis was encountered more frequently in patients with genotype C. During a mean follow-up period of 26.3 ± 9.8 months, patients with genotype B had a lower overall tumor recurrence rate than those with genotype C (22% vs. 46%; P = 0.04). Stepwise multiple Cox proportional hazards regression analysis showed that multiplicity of tumor (hazard ratio, 6.84; 95% confidence interval [CI], 1.45-32.2; P = 0.02) was associated with tumor recurrence, whereas genotype C and age were associated with borderline significance (P = 0.06). Stratified analysis showed that genotype C was still associated with tumor recurrence in cirrhotic patients with borderline significance by univariate analysis (hazard ratio, 3.8; 95% CI, 0.84-17.6; P = 0.07). However, cumulative 2-year survival rates were similar between patients with genotype B and C (92% vs. 85%; P = 0.23). Conclusions: Our data suggest that patients with HCC with genotype C have a greater tumor recurrence rate after curative resection of HCC compared with those with genotype B. Prolonged follow-up is needed to clarify the impact of HBV genotype on postoperative outcome.




Chen, J. D., Liu, C. J., Lee, P. H., Chen, P. J., Lai, M. Y., Kao, J. H., & Chen, D. S. (2004). Hepatitis B genotypes correlate with tumor recurrence after curative resection of hepatocellular carcinoma. Clinical Gastroenterology and Hepatology, 2(1), 64–71. https://doi.org/10.1016/S1542-3565(03)00293-3

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