PCOS more often becomes the condition affecting not only adult women, but also girls. It is a problem of the whole societies of developed countries, which contributes to self-assessment, attractiveness and ability to have children. We ask for the reasons why there is an increasing number of adult and young women with polycystic ovaries in ultrasound examination and with menstrual disorders, who less frequently have significantly elevated levels of androgens. Currently, women differing in phenotypes are diagnosed as having the same disease. We assume that the standard treatment procedures may not be ideal for all the patients, because the mechanisms of disease development, including inflammatory processes, may differ and be of various intensity. The aim of the study was to investigate the response patterns of insulin-like growth factor 1 (IGF-1) and tumor necrosis factor alpha (TNF)-a in patients with polycystic ovary syndrome (PCOS) who underwent high glycemic index diet. The majority of patients with PCOS followed high glycemic index diet (HGID). 97.26% of patients that could be potentially included in our study followed high glycemic index diet. We were wondering if this way of nutrition had an impact on their metabolic disorders. We combined the effect of HGID with the development of PCOS and theory and the TNF-alpha and IGF-I pathways.
Szczuko, M., Zapałowska-Chwyć, M., Maciejewska, D., Drozd, A., Starczewski, A., & Stachowska, E. (2016). High glycemic index diet in PCOS patients. The analysis of IGF I and TNF-α pathways in metabolic disorders. Medical Hypotheses, 96, 42–47. https://doi.org/10.1016/j.mehy.2016.09.016