The methoxycarbonylation of styrene has been studied using Pd(OAc)2/L/acid catalytic systems with L being chiral ferrocene- and biphosphole-based ligands. Good activities are obtained in mild conditions. Chemoselectivities and regioselectivities (up to 98% in favour of the branched isomer) are excellent but enantioselectivities remain moderate (ee up to 17%). © 2008 Elsevier Ltd. All rights reserved.
Diab, L., Gouygou, M., Manoury, E., Kalck, P., & Urrutigoïty, M. (2008). Highly regioselective palladium-catalyzed methoxycarbonylation of styrene using chiral ferrocene- and biphosphole-based ligands. Tetrahedron Letters, 49(35), 5186–5189. https://doi.org/10.1016/j.tetlet.2008.06.057