High-resolution optrode with integrated light source for deeper brain regions

Abstract

This work reports on the design, assembly, and the optical as well as thermal properties of a polymer-based optrode with integrated light source to be applied in optogenetic experiments. In parallel to electrical recordings of brain activity using macroelectrodes and microelectrodes, the enhanced depth probe enables the optical stimulation of neural tissue using integrated light emitting diodes (LEDs). A hollow cylindrical polyimide (PI) probe carries the electrodes and their wiring to a connector part while the LED is positioned within the cylindrical probe and electrically connected via a separate PI cable.