Transcriptional latency of integrated HIV-1 provirus represents a major obstacle to curing HIV. In this issue of Cell Host & Microbe, Boehm et al. (2017) identify a new lysine methyltransferase that writes a repressive histone mark associated with HIV-1 latency. The results are important for strategies to pharmacologically reverse HIV-1 latency.
Nikolai, B. C., & Feng, Q. (2017, May 10). HIV Latency Gets a New Histone Mark. Cell Host and Microbe. Cell Press. https://doi.org/10.1016/j.chom.2017.04.012