HIV-1-induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo

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Abstract

Direct and indirect cytopathic mechanisms have been proposed to account for the loss of CD4+ T cells after infection with human immunodeficiency virus type 1 (HIV-1). We report here that HIV-1 infection of the human thymus in vivo results in thymocyte depletion by at least two different mechanisms. Thymocytes within multiple stages of differentiation are induced to die of apoptosis; most of these cells are uninfected. Additionally, thymopoiesis is interrupted by direct infection and destruction of intrathymic CD3-CD4+CD8- progenitor cells. These mechanisms are differentially induced by distinct isolates of HIV-1. © 1995.

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Su, L., Kaneshima, H., Bonyhadi, M., Salimi, S., Kraft, D., Rabin, L., & McCune, J. M. (1995). HIV-1-induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo. Immunity, 2(1), 25–36. https://doi.org/10.1016/1074-7613(95)90076-4

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