HLA-G orchestrates the early interaction of human trophoblasts with the maternal niche

23Citations
Citations of this article
36Readers
Mendeley users who have this article in their library.

Abstract

Extravillous trophoblasts (EVTs) play a central role in educating maternal leukocytes, endometrial stromal and endothelial cells to generate a receptive decidual microenvironment tailored to accept the semi-allogeneic fetus. HLA-G, a non-classical HLA class I molecule endowed with immune-regulatory functions, is primarily expressed on EVTs lining the placenta and on the naturally occurring tolerogenic dendritic cells, named DC-10, which are enriched in the human first trimester decidua. Decidual DC-10 are involved in HLA-G-mediated tolerance at the maternal-fetal interface. EVTs not only establish a tolerogenic microenvironment through the interaction with maternal innate and adaptive cells but also orchestrate placenta vascular and tissue remodeling, leading to a successful pregnancy. Here, we discuss the potential implications of the HLA-G-mediated cross-talk among the cells present at the maternal-fetal interface, and its role in maintaining a positive relationship between the mother and the fetus.

Cite

CITATION STYLE

APA

Gregori, S., Amodio, G., Quattrone, F., & Panina-Bordignon, P. (2015). HLA-G orchestrates the early interaction of human trophoblasts with the maternal niche. Frontiers in Immunology, 6(MAR). https://doi.org/10.3389/fimmu.2015.00128

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free