Membrane binding of viral and cellular N-myristoylated proteins can be regulated by selectively sequestering myristate. In this issue of Cell Host & Microbe, Zhu et al. (2017) report on a myristate binding site within the cellular protein heme oxygenase-2 that acts as a trap to inhibit N-myristoylated protein function.
Resh, M. D. (2017, February 8). HO-2 Pockets Myristoylated Gag. Cell Host and Microbe. Cell Press. https://doi.org/10.1016/j.chom.2017.01.011