Hormaomycins B and C: New antibiotic cyclic depsipeptides from a marine mudflat-derived Streptomyces sp.

15Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.

Abstract

Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were discovered from a marine mudflat-derived actinomycete, Streptomyces sp., collected in Mohang, Korea. The planar structures of the hormaomycins, which bear structurally-unique units, such as 4-(Z)-propenylproline, 3-(2-nitrocyclopropyl)alanine, 5-chloro-1-hydroxypyrrol-2-carboxylic acid and b-methylphenylalanine, were established as the first natural analogues belonging to the hormaomycin peptide class. The absolute configurations of 1 and 2 were deduced by comparing their CD spectra with that of hormaomycin. These hormaomycins exhibited significant inhibitory effects against various pathogenic Gram-positive and Gram-negative bacteria.

Cite

CITATION STYLE

APA

Bae, M., Chung, B., Oh, K. B., Shin, J., & Oh, D. C. (2015). Hormaomycins B and C: New antibiotic cyclic depsipeptides from a marine mudflat-derived Streptomyces sp. Marine Drugs, 13(8), 5187–5200. https://doi.org/10.3390/md13085187

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free