A human gene encoding morphine modulating peptides related to NPFF and FMRFamide

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Abstract

FMRFamide-related peptides have been isolated from both invertebrates and vertebrates and exhibit a wide range of biological effects in rats. We show here that in humans 2 FMRFamide-related peptides are encoded by a single gene expressed as a spliced mRNA. The larger predicted peptide (AGEGLNSQFWSLAAPQRFamide) differs from the peptide isolated from bovines (AGEGLSSPFWSLAAPQRFamide) by the substitutions of 2 amino acids. The shorter predicted peptide NPSF, SQAFLFQPQRFamide) is 3 amino acids longer than the bovine 8 amino-acid NPFF (FLFQPQRFamide) or the human NPFF peptide isolated from serum [5] suggesting that the encoded protein is subject to cleavage by a tripeptidyl peptidase or by a novel processing mechanism. On rat spinal cord, the larger peptide is indistinguishable in activity from the equivalent bovine peptide whereas the smaller extended peptide is inactive.

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Perry, S. J., Huang, E. Y. K., Cronk, D., Bagust, J., Sharma, R., Walker, R. J., … Burke, J. F. (1997). A human gene encoding morphine modulating peptides related to NPFF and FMRFamide. FEBS Letters, 409(3), 426–430. https://doi.org/10.1016/S0014-5793(97)00557-7

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