Objective: To report on a human immunodeficiency virus (HIV)-infected patient with uveitis and an intraocular HIV1 RNA load largely exceeding that of plasma and no evidence of other intraocular infectious agents causing uveitis than HIV itself. Design: Interventional case report. Participant: A 37-year-old male HIV-infected patient with uveitis and no retinal manifestations. Methods: Clinical and laboratory examinations including extensive intraocular fluid analyses for various pathogens and HIV-1 RNA loads in the aqueous and plasma. Main Outcome Measures: Results of aqueous analysis and ophthalmologic features. Correlations between the results of aqueous testing and clinical characteristics. Results: A 37-year-old patient presented with progressive uveitis. He was positive for HIV-1, and his HIV-1 RNA plasma load was 44,600 copies/mL. His intraocular HIV-1 RNA load was >1,900,000 copies/mL, which largely exceeded his concurrent plasma load. No evidence of infectious agents other than HIV itself was found, and the uveitis reacted promptly to solely the antiretroviral treatment. Conclusions: Our findings suggest that HIV can locally replicate within the eye and cause an intraocular inflammatory reaction. Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article. © 2008 American Academy of Ophthalmology.
Rothova, A., Schneider, M., & de Groot-Mijnes, J. D. F. (2008). Human Immunodeficiency Virus-induced Uveitis: Intraocular and Plasma Human Immunodeficiency Virus-1 RNA Loads. Ophthalmology, 115(11), 2062–2064. https://doi.org/10.1016/j.ophtha.2008.04.034