Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures

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Abstract

Type 2 diabetes mellitus (DM) and Alzheimer's disease (AD) share epidemiological and biochemical features. Both are characterized by insoluble protein aggregates with a fibrillar conformation - amylin in Type 2 DM pancreatic islets, and Aβ in AD brain. To determine whether amylin shares neurotoxic properties with Aβ, we incubated hippocampal and cortical neurons with Aβ42 and human amylin. Different from non-amyloidogenic rat amylin, both caused a dose-, time- and cell type-specific neurotoxicity supporting the notion of a similar toxic mechanism. Depending on the cell type, this finding is also supported by co-incubation of human amylin and Aβ. © 2008 Federation of European Biochemical Societies.

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Lim, Y. A., Ittner, L. M., Lim, Y. L., & Götz, J. (2008). Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures. FEBS Letters, 582(15), 2188–2194. https://doi.org/10.1016/j.febslet.2008.05.006

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