Humanized Rag2 -/- γc -/- (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year

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Abstract

HIV-1 infection is characterized by life-long viral persistence and continued decline of helper CD4 T cells. The new generation of humanized mouse models that encompass RAG-hu, hNOG and BLT mice have been shown to be susceptible to HIV-1 infection and display CD4 T cell loss. Productive infection has been demonstrated with both R5 and X4 tropic strains of HIV-1 via direct injection as well as mucosal exposure. However the duration of infection in these mice was evaluated for a limited time lasting only weeks post infection, and it is not established how long the viremia can be sustained, and if the CD4 T cell loss persists throughout the life of the infected humanized mice. In the present study we followed the HIV-1 infected RAG-hu mice to determine the long-term viral persistence and CD4 T cell levels. Our results showed that viremia persists life-long lasting for more than a year, and that CD4 T cell levels display a continuous declining trend as seen in the human. These studies provide a chronic HIV-1 infection humanized mouse model that can be used to dissect viral latency, long-term drug evaluation and immune-based therapies. © 2009 Elsevier Inc. All rights reserved.

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Berges, B. K., Akkina, S. R., Remling, L., & Akkina, R. (2010). Humanized Rag2 -/- γc -/- (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year. Virology, 397(1), 100–103. https://doi.org/10.1016/j.virol.2009.10.034

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