Humanized Rag2 -/- γc -/- (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year

Citations of this article
Mendeley users who have this article in their library.


HIV-1 infection is characterized by life-long viral persistence and continued decline of helper CD4 T cells. The new generation of humanized mouse models that encompass RAG-hu, hNOG and BLT mice have been shown to be susceptible to HIV-1 infection and display CD4 T cell loss. Productive infection has been demonstrated with both R5 and X4 tropic strains of HIV-1 via direct injection as well as mucosal exposure. However the duration of infection in these mice was evaluated for a limited time lasting only weeks post infection, and it is not established how long the viremia can be sustained, and if the CD4 T cell loss persists throughout the life of the infected humanized mice. In the present study we followed the HIV-1 infected RAG-hu mice to determine the long-term viral persistence and CD4 T cell levels. Our results showed that viremia persists life-long lasting for more than a year, and that CD4 T cell levels display a continuous declining trend as seen in the human. These studies provide a chronic HIV-1 infection humanized mouse model that can be used to dissect viral latency, long-term drug evaluation and immune-based therapies. © 2009 Elsevier Inc. All rights reserved.




Berges, B. K., Akkina, S. R., Remling, L., & Akkina, R. (2010). Humanized Rag2 -/- γc -/- (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year. Virology, 397(1), 100–103.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free