Hyaluronan reduces migration and proliferation in CHO cells

Citations of this article
Mendeley users who have this article in their library.


Expression of the hyaluronan synthase gene in hyaluronan-deficient CHO cells changed the cell morphology from a spindle shape to a flattened epithelial-type form. Hyaluronan producing CHO cells showed reduced initial cell adhesion, migration, proliferation and density at contact inhibition, but no difference in random migration determined by the Boyden chamber assay. Addition of hyaluronan to the medium of CHO cells reduced migration, proliferation and initial cell adhesion. In contrast, coating the plastic dish with hyaluronan enhanced initial cell adhesion. These results are discussed in the context of the perplexing properties of hyaluronan on cellular functions. © 2001 Elsevier Science B.V.




Dübe, B., Lüke, H. J., Aumailley, M., & Prehm, P. (2001). Hyaluronan reduces migration and proliferation in CHO cells. Biochimica et Biophysica Acta - Molecular Cell Research, 1538(2–3), 283–289. https://doi.org/10.1016/S0167-4889(01)00079-9

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free